|Epidemiological Alert: Haemolytic Uraemic Syndrome (HUS) and infection by Enterohaemorrhagic E. coli (EHEC) (Published on 7 June 2011)|
Developed by the Robert Koch Institute to be applied to HUS-cases associated with the 2011 Germany outbreak.
HUS Clinical criteria: A clinical picture of acute enteropathogenic HUS is defined by the presence of at least two of the following three criteria:
1. Hemolytic anemia
2. Thrombocytopenia ≤ 150,000 cells/mm3,
3. Renal dysfunction.
Laboratory confirmed cases: Positive result in at least one of the following tests:
Detection of Shigatoxin
Indirect (serological) detection
Suspect HUS case: Case with a clinical picture of acute enteropahogenic HUS as assessed by the attending physician, but not formally meeting the clinical criteria (at least two of three) identified above, are classified as suspect cases regardless of laboratory confirmation.
Regional Office for the Americas of the World Health Organization