Neglected Infectious Diseases List
Schistosomiasis is a parasitic infection caused by trematode species belonging to the genus Schistosoma: the only type of schistosomiasis transmitted in the Americas is intestinal schistosomiasis caused by Schistosoma mansoni. Adult worms in the human host measure about 1 cm (male) and 1.5 cm (female). The male is canal-shaped and lodges the female, so that they are usually found together.
1,6 million infected individuals in Brazil and Venezuela require treatment for schistosomiasis; in contrast, transmission in St. Lucia and Suriname is from low to very low. Epidemiological assessments are being implemented in the Dominican Republic and are planned in Puerto Rico to verify whether transmission of schistosomiasis has been interrupted, as cases have not been reported for a long time.
Life cycle of the parasite
In order to complete its life cycle, S. mansoni requires a final host (the human being, as there is no significant animal reservoir) and an intermediate host (a freshwater snail of the genus Biomphalaria, Bulinus o Oncomelania).
The adult worms live in the smallest branches of the intestinal mesenteric veins of infected individuals, where they lay eggs which reach the intestinal lumen and are passed in the faeces. When the faeces reach freshwater sources, the eggs hatch into larvae called miracidia. Miracidia find their way to suitable water snails where they reproduce asexually and generate another type of larvae, called cercariae, which escape the snail and are released into the water. Transmission to humans occurs when the cercariae, which swim freely, penetrate the skin of humans bathing for professional or recreational purposes. Once in the human body, as schistosomula (young worms), they penetrate blood vessels and finally reach the portal venous system of the liver, where they mature into adult worms and finally migrate to the intestinal venules, where they start laying eggs, thus closing the cycle.
Signs and symptoms
Intestinal schistosomiasis gives rise to both early and chronic symptoms. Early symptoms such as pruritic rash are associated with skin penetration of the cercariae. Chronic symptoms are associated with the granulomatous inflammation that surrounds the eggs trapped within the biological tissues. Granulomas can be found in the intestinal wall (mainly the distal colon portion) and can be responsible for blood in the stools and abdominal pain. Most of the symptoms are however caused by embolization of the eggs from the intestinal veins to the liver, through the portal system. Here, granulomas are found in the periportal spaces and tend to merge progressively thus leading to periportal “pipestem” fibrosis. Severe cases are associated with obstruction of portal blood flow and portal hypertension, thus eliciting a clinical picture characterized by splenomegaly, ascites and bleeding esophageal varices which are a frequent cause of death.
A suggestive clinical picture and a history of contact with freshwater sources can orientate the diagnosis. Microscopic identification of eggs in stool samples remains the most widely used diagnostic technique, even though it can give falsely negative results in the earliest stages of the infection, when egg deposition has not started yet. The Kato-Katz thick-smear technique is the one recommended by WHO for community diagnosis and assessment of the endemic status of schistosomiasis in a given geographical area. Tests relying on detection of circulating antigens in serum and urine samples are available but not very sensitive specially in low endemic areas; tests detecting antibodies are the most sensitive available and are consequently used to assess the existence of residual transmission of schistosomiasis in areas where control measures have been implemented; they cannot however distinguish between current and past infections. Imaging techniques such as ultrasound are helpful complementary tools in staging the severity of the liver fibrosis.
Treatment, prevention and control
Praziquantel (PZQ) is the first therapeutic option for of schistosomiasis recommended dosage is 40-60 mg/kg, single-administration. It has high cure and egg reduction rates and is associated with only mild and temporary adverse events. In endemic areas, in order to facilitate treatment activities, PZQ can be administered by using the WHO dose-pole, which calculates the appropriate dosage by height instead of weight.
Oxamniquine is another medicine that can be used to treat S. mansoni schistosomiasis. It is administered at the dosage of 15 mg/kg, single-administration. Although a safe drug, oxamniquine is less used than PZQ due to lower cure and egg reduction rates.
The mainstay of the WHO-recommended strategy to control schistosomiasis in endemic areas is the large-scale distribution of PZQ to high-risk target groups (school-age children, women of childbearing age including pregnant women, individuals professionally exposed to frequent contact with fresh water), or to the entire resident population. The aim of the strategy is to keep, through treatment at regular intervals, the worm burden in infected individuals low, so as to prevent the development and the progression of morbidity and reduce transmission. It is also important to address the social determinants of health that can perpetuate the cycle of disease transmission, such as access to safe water, improved sanitation and health education.
In areas where prevalence is very low, and where sensitive diagnostic tests are easily affordable and available, regular screening and selective chemotherapy of positive cases can also be an option.
In 2009, PAHO’s Directing Council Resolution CD49.R19 urged Member States to take measures against schistosomiasis and drastically reduce its prevalence in the Americas.  As a number of countries in the Americas are approaching low transmission status as a result of many years of control interventions, a strategy for interruption of transmission is also being developed with support from PAHO/WHO. It is hoped that such combined approach will produce a “final push” and will make the Americas free from the burden of schistosomiasis in a near future.
- In October 2009, PAHO passed Resolution CD49.R19 on the Elimination of Neglected Infectious Diseases and Other Poverty-related Infections, urging Member States to take measures against schistosomiasis (and other neglected infectious diseases) to drastically reduce its prevalence in the Americas. The goal for 2015 in this resolution is to reduce the prevalence and burden of schistosomiasis in areas of high transmission to less than 10%, according to quantitative measurements of parasite egg counts in feces.
- In May 2012, the World Health Assembly adopted the Resolution WHA65.21, which called on endemic countries to reduce transmission of schistosomiasis and accelerate elimination of the disease.
- In May 2013, the World Health Assembly adopted the Resolution WHA 66.12, and endorsed goals for 17 neglected infectious diseases, including schistosomiasis, by 2020.
- In June 2013, the Organization of the Americas States (AG/RES.2810(XLIII-O/13) endorsed the resolution CD49.R19 and 23 countries approved the OAS resolution.
- PAHO/WHO collaborates with endemic countries to obtain donated medicines and other necessary supplies to achieve interruption of transmission and elimination of schistosomiasis. PAHO/WHO also provides technical cooperation for monitoring, prevention, and control (e.g: through mapping of distribution of the disease), and helps endemic countries prepare to obtain verification of elimination of the disease from PAHO/WHO.