|Name:||International Conference on the Radiological Protection of Patients Malaga, Spain 26-30 March 2001 Working Material-Contributed Papers Part III.|
The biodistribution of radiopharmaceuticals may be modified by drug interaction. Unknowledge of such factor can induce a poor misvisualization of the scintigraphy images, leading to the repetition of the examination, increasing the radiation dose for the patient. We are trying to develop a model to evaluate the influence of drugs on the biodistribution of radiopharmaceuticals. Mitomycin-C is a drug that has been used as a component of many chemotherapeutic regimens. We have studied the effect of mitomycin-C on the biodistribution of the pyrophosphate labeled with technetium-99m. These results can be justified by the metabolic process and/or the therapeutical effect of mitomycin-C and this alteration on the biodistribution of the studied radiopharmaceutical was capable to increase the radiation dose in some organs.
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|Created On:||09/01/2010 12:00|
|Last updated on:||09/01/2010 12:02|