Globally, viral hepatitis represents a high burden of disease and mortality. It is estimated that 57% of cases of liver cirrhosis and 78% of cases of primary liver cancer are due to hepatitis B or C virus infections. Recognizing the important public health problem by hepatitis, in 2010, the 63rd World Health Assembly designated July 28 as the World Hepatitis Day and called for a comprehensive response in the fight against hepatitis. Since then, PAHO and WHO have mobilized to join efforts and develop strategies to combat hepatitis at both global and regional levels.