The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic. Since the INS records do not include clinical variables of comorbidity in the total number of cases reported as positive, but only in patients with fatal outcome, comorbidities, age and sex available in the daily INS reports were reviewed. Their frequency was identified and mortality risk behavior for the analyzed variables was established and compared with the behavior described in the international literature. Of the 100 cases, 63 were male, the mean age was 65.75 ± 18.11 years, and in 22 of them no comorbidity had been reported. The most frequently reported comorbidities were arterial hypertension (35%), diabetes mellitus (21%), cardiovascular and cerebrovascular disease (19%), chronic obstructive pulmonary disease (16%), obesity (12%), smoking (9%) and thyroid disease (8%). Patients over 60 years of age presented a higher risk of mortality (OR 10.31, IC95% 6.67-15.94, p < 0.0001). Ten percent of the deceased patients were under 60 years of age and did not present comorbidity.