In the Region of the Americas, the number of people requiring care from others will continue to grow rapidly. The issue of long-term care call for a long-term solution that will address the demographic and epidemiological shift facing the Region. This policy brief outlines the current situation and presents the challenges in terms of human resources, financing, and monitoring and evaluation. It encourages countries to take the opportunity to develop a strategic solution for long-term care by, among others, prioritizing the issue, investing in appropriate systems, ensuring proper funding, developing evidence, and measuring progress. It is targeted at those involved in policymaking on long-term care at country and regional level.