Situation Report: Mpox Multi-Country Outbreak - Region of the Americas - 25 April 2025

Between 2022 and 31 March 2025, a total of 137,892 confirmed cases of mpox have been reported globally, from 127 countries and territories. The Region of the Americas (49.7%) contributes the largest proportion of cases, followed by the African (23.4%) and European (21.4%) Regions.

This document provides highlights of the epidemiological situation in the Region of the Americas and the PAHO/WHO response.