Situation Report: Mpox Multi-Country Outbreak - Region of the Americas - November 2025

Between 2022 and 31 October 2025, a total of 168,736 confirmed cases of mpox have been reported globally, from 142 countries and territories. The Region of the Americas (42.4%) contributes the largest proportion of cases, followed by the African (36.2%) and European (18.5%) Regions.

In the Region of the Americas, a cumulative total of 71,483 confirmed cases of mpox, including 154 deaths, were reported in 31 countries and territories between 2022 and 2025.

In 2025, a total of 16 countries (Argentina, Bolivia (Plurinational State of), Brazil, Canada, Chile, Colombia, Costa Rica, Ecuador, Guatemala, Honduras, Jamaica, Mexico, Panama, Paraguay, Peru, and the United States) have reported 3,815 mpox cases, including three deaths, all in Mexico.

In the last three months, five new clade Ib cases have been confirmed in the Americas (United States: n=4; Canada: n=1), bringing the regional cumulative total of clade Ib cases to 12. To date, the United States (n=9 cases), Canada (n=2 cases), and Brazil (n=1case) remain the only countries in the Region to have reported cases of mpox clade Ib.