Acute, severe hepatitis of unknown origin in children. 10 May 2022

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This technical note follows the previous reports regarding the event of acute, severe hepatitis of unknown origin in children disseminated by the Pan American Health Organization / World Health Organization (PAHO/WHO) on 23 April 2022 (two reports)1, 25 April 2022, and 29 April 2022.

This event was first reported by the United Kingdom International Health Regulations (IHR) National Focal Point on 5 April 2022, referring to 10 cases of severe acute hepatitis of unknown etiology in previously healthy young children (ages ranging from 11 months to 5 years old) in Scotland. To date, 348 probable cases have been reported in 21 countries, with 26 children requiring liver transplantation. Fifteen countries have reported 5 or fewer cases.

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