The Program Budget of the Pan American Health Organization 2022–2023 is the second to be developed and implemented under the Strategic Plan of the Pan American Health Organization 2020–2025. It sets out the corporate results and targets for the Pan American Health Organization (PAHO) for the next two years. It presents the budget that the Pan American Sanitary Bureau will require in order to deliver on these biennial results and support Member States in improving health outcomes while contributing to the achievement of health targets set out in existing regional and global frameworks. The results framework of the Program Budget responds to the main strategic mandates for the period: the Thirteenth General Programme of Work of the World Health Organization (WHO), the WHO Programme Budget 2022–2023, the Sustainable Health Agenda for the Americas 2018–2030, and the PAHO Strategic Plan 2020–2025. Its implementation will also contribute to progress toward the Sustainable Development Goals. Moreover, this is the first Program Budget to be developed during the COVID-19 period, and many aspects of it have been shaped by the consequences and lessons learned from the protracted emergency.