What’s the 2+1+1? Event-driven oral pre-exposure prophylaxis to prevent HIV for men who have sex with men: Update to WHO’s recommendation on oral PrEP. Technical brief

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What’s in this technical brief?

This technical update by the World Health Organization (WHO) aims to:

  • update the dosing considerations for oral pre-exposure prophylaxis (PrEP) containing TDF for men who have sex with men;
  • summarize current evidence on the safety and efficacy of event-driven PrEP (ED-PrEP);
  • describe the rationale for offering ED-PrEP as an alternative to daily oral PrEP to men who have sex with men as part of comprehensive HIV prevention and sexual health services;
  • discuss considerations for offering ED PrEP to men who have sex with men, including clear messaging on how men who have sex with men can switch from ED-PrEP to daily dosing (and vice-versa).