Washington, D.C., 14 January 2026 (PAHO) – Drug use disorders are a major and growing public health problem in the Americas. Drug use is among the top 10 risk factors contributing to all-cause mortality and disability in the Region, according to findings published in the Pan American Journal of Public Health.
In 2021, an estimated 17.7 million people in the Americas were living with a drug use disorder, resulting in nearly 78,000 deaths directly attributable to these disorders, representing a mortality rate four times higher than the global average.
The study, based on analyses of data from the Global Burden of Disease 2021, revealed that drug use disorders are primarily underpinned by opioid use and disproportionately affect young men.
Opioid use disorders accounted for more than 75% of all drug use disorder–related deaths. Disability-adjusted life years (DALYs) linked to drug use disorders nearly tripled between 2000 and 2021, increasing at an average rate of almost 5% per year. Young adults, particularly men, experienced the highest burden, while deaths among women also increased, raising additional concern.
“Drug use disorders are a preventable and treatable public health problem, yet they are taking an increasing toll on families and communities across our Region,” said PAHO Director Dr. Jarbas Barbosa. “Countries must urgently scale up evidence-based prevention, treatment, and harm reduction services—especially for young people and those at higher risk.”
A growing and diverse threat
The landscape of drug use disorders varies significantly across the Region. In North America, the study highlights a sharp increase in disorders related to opioids—particularly highly potent synthetic opioids such as fentanyl—as well as amphetamines. In contrast, the main contributors to drug use disorders in the Caribbean, Central America, and South America over the past decade have been cannabis and cocaine use.
The authors estimate that 145,515 all-cause deaths in the Americas in 2021 resulted from conditions such as opioid overdose, liver cancer, cirrhosis, and suicide attributable to drug use. This places drug use among the top 10 risk factors contributing to mortality and disability in the Region, alongside high blood pressure, high body-mass index (overweight/obesity), dietary risks, and tobacco use.
Significant increases in opioid and amphetamine use disorders were observed during the COVID-19 pandemic. Crisis-related stress, disruptions in health services, and social isolation may have intensified existing vulnerabilities and contributed to the increase in drug-related deaths during this period.
PAHO calls for urgent, integrated action
The study’s findings underscore critical gaps in prevention, access to treatment, and harm reduction services across the Americas.
PAHO urges countries to strengthen drug prevention programs targeting youth and high-risk populations; expand access to treatment and harm reduction, including medication-assisted treatment for opioid use disorders; integrate substance use services into primary health care and community-based services; improve surveillance and data systems to detect emerging trends, particularly those involving synthetic opioids and combined drug use; and ensure gender-responsive approaches, given the growing burden among women.
Tools such as the Alcohol Use Disorders Identification Test (AUDIT) and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), developed by WHO, are recognized as cost-effective strategies to reduce harm and close the treatment gap.
“We must place mental health and substance use care at the center of our health systems,” said Dr. Renato Oliveira E Souza, chief of the Mental Health and Substance Use Unit at PAHO. “Community-based, people-centered services, supported by strong public health leadership and national strategies informed by epidemiological patterns, can reverse these trends and save thousands of lives across the Americas.”
Note to Editors
The following definitions are included for context and background:
• Drug use disorders (DUD) refer to conditions in which the repeated use of psychoactive substances—such as opioids, cocaine, amphetamines, or cannabis—leads to significant impairment in physical health, mental health, or daily functioning. These disorders can include dependence, harmful use, withdrawal symptoms, and drug-related medical complications.
• Opioid use disorders (OUD) involve the problematic or harmful use of opioid drugs—including prescription pain medications, heroin, and synthetic opioids like fentanyl—that leads to dependence, overdose risk, and other severe health consequences.
